Creatine is good for your brain, not just muscles

June 23, 2024

Athletes have been using creatine supplementation for over 30 years. It seems to improve the energy supply to muscle tissues and increase fat-free mass. Creatine also supplies energy to nerve cells in the brain. Taking a creatine supplement increases the levels of creatine in muscles and the brain.

A review of six studies suggested that creatine improves short-term memory, intelligence, and reasoning. Creatine did not improve any cognitive abilities in young people. Vegetarians benefited more than non-vegetarians in memory tasks.

A study by Taiwanese researchers published in Cephalalgia showed reduced creatine levels in the thalamus (the pain-processing area in the brain) in patients with medication-overuse headaches.

Greek doctors published a report, Prevention of traumatic headache, dizziness and fatigue with creatine administration. A pilot study. They studied 39 patients who sustained a severe traumatic brain injury. There were 19 patients in the control group and 20 in the active group. The active group was given 0.4 g/kg of creatine. Treatment was administered within 4 hours of injury and was continued for 6 months. This treatment improved the duration of post-traumatic loss of memory, the duration of being on a respirator, and the duration of stay in an intensive care unit. They also showed improvement in headaches, dizziness, and fatigue. No side effects were reported.

Some studies suggest that creatine can improve bone health. Here is what WebMD says about creatine:

“While most people get low amounts of creatine by eating seafood and red meat, larger amounts are found in synthetic creatine supplements. Your pancreas and kidneys can also make around 1 gram of creatine each day. Creatine is one of your body’s natural energy sources.

Nearly 95% of the creatine in your body is stored in your skeletal muscles and is used during physical activity. As a dietary supplement, creatine is commonly used to improve exercise performance in athletes and older adults.”

There is not enough evidence to routinely recommend creatine for the treatment of migraine headaches. I do, however, recommend to my older patients taking 5 to 7  grams of creatine an hour before or after exercise.  I am 67 and do take it when I exercise.

Written by
Alexander Mauskop, MD
Continue reading
July 18, 2026
Alternative Therapies
Why Everyone Should Have Their Vitamin D Level Checked, And Why 'Normal' Isn't Good Enough
Vitamin D deficiency is common, often missed, and easy to correct. In this post I explain why “normal” lab values can be misleading, how vitamin D affects headaches, heart and brain health, and what levels and doses I recommend for my patients.
Read article
July 13, 2026
Brain disorders
fMRI-guidedTMS targeting improves outcomes
This post reviews new data showing that fMRI‑guided, connectivity‑based TMS targeting improves response rates in treatment‑resistant depression and likely other conditions. By mapping each patient’s brain circuits, clinicians can move beyond a one‑size‑fits‑all DLPFC target to condition‑specific and patient‑specific sites, a particularly important advance for migraine and network‑based pain disorders.
Read article
July 3, 2026
Alternative Therapies
Essential Oils Can Change Your Brain
The science of essential oils and the brain is still young, but the findings so far are more compelling than many people realize. Brain imaging studies show that common scents like rose, lavender, peppermint, and lemon produce measurable changes in brain structure, brain activity, and pain processing. These studies are small and preliminary, and essential oils are not a substitute for medical treatment. But the evidence suggests that what we smell can influence the brain in real, physical ways
Read article
Insights from Dr. Alexander Mauskop on headaches and migraines
Subscribe to the Blog.
Subscribe
Subscribe