Photophobia, or sensitivity to light is one of the most common symptoms that accompany a migraine attack. Many patients remains photophobic even after the headache has resolved. In some, a prolonged exposure to bright light or as little as a momentary reflection of the sun in the window glass or water surface can bring on a severe attack.

It is not unusual for some of my patients to wear sunglasses indoors. Once, when I had a migraine while driving at night I had to put on my sunglasses because the headlights of oncoming cars made the pain worse (luckily, I had a sumatriptan injection with me and as soon as I got off the highway and to a traffic light, I gave myself a shot).

Dr. Kathleen Digre, a professor Neurology and Ophthalmolgy at the University of Utah, whose article on dry eyes and migraines I quoted a couple of years ago, recently stated that staying in the dark may actually make photophobia worse. It may be better to gradually expose yourself to more light when you are not in the middle of an attack.

A small study suggested that people who suffer from photophobia between migraine attacks are more likely to experience anxiety and depression than those without photophobia between attacks and those without migraines. It is not clear if anxiety and depression in these patients is due to more severe migraines.

Treatments for photophobia mentioned by Dr. Digre include botulinum toxin (Botox) injections, nerve blocks, medications such as gabapentin, and a natural supplement, melatonin. I should add that any effective acute and preventive treatment that leads to reduced frequency and duration of the attacks can lead to a reduction in photophobia. Effective treatment is also likely to improve phonophobia (sensitivity to noise) and osmophobia (sensitivity to smells), which are somewhat less common.

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Postconcussion symptoms can be debilitating and can persist for long periods of time, both in kids and adults. Persistence of headaches, dizziness, difficulty concentrating and with memory is often compounded by depression and anxiety. The usual care consists of mild exercises, sleep medications, antidepressants, and other drugs.

A new study published in Pediatrics shows very promising results from cognitive-behavioral therapy (CBT) in teens with post-concussion symptoms. Children aged 11 to 17 years with persistent symptoms for more than a month after sports-related concussion were randomly assigned to receive collaborative care that included CBT (25 kids) or care as usual (24 kids). The children were assessed before treatment and after 1, 3, and 6 months.

Six months after the baseline evaluation 13% of children who received CBT and 42% of control patients reported high levels of postconcussive symptoms. Depression improved by at least 50% in 78% of the CBT group and 46% of control patients. Anxiety symptoms were at the same level in both groups.

CBT has been shown to be effective in children and adolescents with chronic migraines, so it is not surprising that it would also help with postconcussion headaches and other symptoms. And the effect is quite dramatic.

A major obstacle for wider adoption of CBT is the cost and difficulty in finding a qualified psychologist. In a previous post I mentioned two very effective and scientifically verified online programs, ThisWayUp and moodGYM. These do require persistence and discipline, which in case of teens, parents might be able to provide.

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Beta-blocker propranolol (Inderal) was first approved over 50 years ago for the treatment of hypertension and 10 years later became the first drug to be approved for the prevention of migraine headaches. Beta-blockers that followed, including atenolol, timolol, nebivolol, and other, also work for the prevention of migraines. Beta-blockers are also used to treat benign essential or familial tremor, performance anxiety, and other disorders.

A study recently published in Arthritis Care and Research suggests that beta-blockers also reduce arthritis pain. The researchers evaluated 873 patients who suffered from painful osteoarthritis of the hip and/or knee as well as hypertension and who were taking at least one anti-hypertensive medication. Their analysis took into account age, gender, body mass index (BMI), knee or hip osteoarthritis, history of joint replacement, anxiety and depression. The result of this sophisticated analysis showed that patients who were taking beta-blockers had less pain than patients taking other anti-hypertensive medications. Patients taking beta-blockers were also found to be taking less of opioid (narcotic) and other prescription pain medications.

This type of study shows a correlation between the use of certain medications and pain, however to prove that beta-blockers are indeed effective for the pain of osteoarthritis or any other type of pain, we need prospective blinded studies. Until we have those kind of studies, which often take years to complete, it seems prudent to consider using beta-blockers as first-line drugs for the prevention of migraines in patients who also suffer from arthritis pain.

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A new electric device is being tested for the treatment of migraine by an Israeli company, Theranica. Transcutaneous electric nerve stimulation (TENS) has been successfully used for the treatment of musculoskeletal disorders for decades. The theory behind it is the so-called gate theory of pain. It is thought that by stimulating larger nerve fibers we can block pain messages sent by smaller pain-sensing nerve fibers.

Cefaly is a TENS device which became available in 2014 and it provides electrical stimulation of the supraorbital nerves in the forehead. Only small studies have been conducted, so it is not clear how well Cefaly relieves migraines. As far as our experience, we at the NY Headache Center usually treat more severely affected patients, so it is possible that the results are better in people with less severe migraines.

The new wireless patch that is being developed by Theranica is applied to the upper arm. The results of the first study of this patch were published in Neurology, the medical journal of the American Academy of Neurology.

The study author, is a well-known neurologist and pain researcher, Dr. David Yarnitsky of Technion Faculty of Medicine in Haifa, Israel. He was quoted saying, “People with migraine are looking for non-drug treatments, and this new device is easy to use, has no side effects and can be conveniently used in work or social settings.”

The patch device is controlled by a smartphone app. It was studied in 71 patients with episodic migraine who had two to eight attacks per month and who were not on any preventive medications for migraines. The device was applied soon after the start of a migraine and kept in place for 20 minutes.

The devices were programmed to randomly give either a very weak stimulation to serve as placebo or different levels of stronger electrical stimulation.

A total of 299 migraine attacks were treated by these 71 patients. Two hours after the start of real treatment, pain was reduced by at least 50% in 64 percent of patients, compared to 26 percent of patients who received the sham stimulation.

Starting treatment early produced better results, which is similar to what we see with all migraine medications as well. None of the participants found the treatment to be painful.

The device is very safe and we hope that the ongoing trial that Theranica is conducting in the US will confirm its efficacy. It is not yet available in this or any other country.

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Cluster headaches are much less common than migraines (less than a million vs 36 million sufferers), but are arguably the most painful type of headaches a man can experience. And it is usually a man because cluster headaches are thought to be 3-5 times more common in men. However, a study just published in Neurology suggests that the ratio of men to women is closer to 2:1.

This study by Danish researchers also established that women suffering from cluster headaches are more often misdiagnosed than men – 61% vs 46%. Consequently, it takes a year longer for a woman to be diagnosed than for a man – 6.5 years vs 5.5 years. But considering how devastating these headaches can be, these numbers are terrible for both sexes.

Cluster headaches get their name from the fact that they occur in clusters – daily or more frequent attacks lasting one to three hours for a period of a month or two, each year and often at the same time of year. One surprising finding of the study is that women are more likely to have chronic cluster headaches (no break from attacks for more than a month) – 44% vs 32%.

The reason for such high rates of misdiagnosis and long delays in diagnosing cluster headaches is that it is a relatively rare type of headaches and that it is easy to mistake cluster for a migraine or a sinus headache. Cluster headache is always one-sided and centers in the eye, which is common with migraines. It is usually accompanied by a runny nose (and tearing with redness of the eye) as occurs with a sinus headache.

But cluster headaches also have very distinctive features that should make the diagnosis easy, if only doctors asked a few questions. I’ve had a fair number of patients who diagnosed themselves after being misdiagnosed by doctors. During a cluster attack patients tend to be restless, pacing around, hitting their fist or even their head against walls, and sometimes screaming from pain, while migraine sufferers tend to stay very quiet since every movement, sound, and light worsen the pain. The fact that these occur every night for an hour or two and then resolve on their own is also a telltale sign. Migraine pain lasts for at least 4 hours and often for a couple of days without a break. Sinus headaches do not come and go and are easy to rule out by a CAT scan, a standard equipment in every emergency room and cluster sufferers do often end up in an ER.

Fortunately, once the correct diagnosis is made, cluster headaches can be treated very effectively in most patients. Some of the treatments overlap with migraines, such as sumatriptan injections, magnesium infusions, occipital nerve blocks, and Botox injections, but other help only cluster headaches. These include a 10-day high-dose course of steroids, oxygen inhalation, high-dose verapamil, lithium, and other.

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With 13 million participants, soccer is the third most popular sport in the US after basketball and baseball. Worldwide, 250 million people play soccer. Unfortunately, a number of studies have linked playing soccer with neurological symptoms. The latest study from the Albert Einstein College of Medicine published in Neurology evaluated 222 amateur soccer players aged 18 and older (mostly in their 20s and 30s) over a two-week period.

The study suggests that playing soccer even without heading the ball is associated with symptoms of a concussion. Those who did not report heading the ball often had unintentional head impacts (head to head, elbow or knee to head, head kicked, etc) and were much more likely to have concussion-related symptoms which were rated as moderate or severe. These symptoms included headache, dizziness, feeling dazed, and other. Unintentional head impacts were experienced by 37% of men and 43% of women, while heading-related symptoms were reported by 20%.

Not all symptoms necessarily represent a concussion and some pain and dizziness could be neck-related, so additional large studies are needed. Some studies have detected brain changes in soccer players who frequently head the ball, but these findings are considered to be preliminary and not conclusive.

According to the US Soccer Federation children under the age of 10 should not be allowed to head the ball in practice or in games. Children aged 11 to 13 are allowed to head the ball only during practice. However, this new study suggests that soccer players of any age may be risking brain injury, mostly from heading and unintentional head injuries.

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Naltrexone, along with naloxone are narcotic (opioid) antidotes, that is they counteract the effect of narcotics and are used to treat overdoses with heroin, fentanyl, Percocet, Vicodin, and other opioid drugs. Surprisingly, low doses of naltrexone (LDN) seem to be effective in treating pain. LDN has been also used to treat symptom in conditions such as depression, fibromyalgia, Crohn’s disease, multiple sclerosis, complex regional pain syndrome (which used to be called reflex sympathetic dystrophy), and autoimmune disorders.

Low dose naltrexone is not a typical pain killer, but may be helping pain by reducing inflammation. Instead of opioid receptors, it works on Toll-like receptor 4 (TLR4) receptors on glial cells. Glial cells surround the nerve cells and play important functions in the brain, beyond just a supporting role that had been assigned to them for many years. Opioid drugs are known to promote inflammation through the brain immune system leading to worsening of pain over time. Recent discoveries have shown that the Toll-like receptors are involved in triggering these inflammatory immune events. These discoveries have led many researchers to look at ways to block TLR4, but so far no such drug has been developed. We do have several existing medications that seem to block TLR4. Besides LDN, amitriptyline (Elavil) and cyclobenzaprine (Flexeril) are two other drugs that block TLR4 and that have been used for years to treat pain.

No large controlled studies of LDN for migraines, pain or any other condition have been conducted to date. Despite the fact that the evidence is only anecdotal and that LDN my work purely through the placebo effect, advantages of LDN are that it is inexpensive and safe. Naltrexone is available in 25 and 50 mg tablets, while the amount used for LDN is between 1.5 to 4.5 mg. This means that it can be obtained only from a compounding pharmacy. Naltrexone is not a controlled substance, but it does require a prescription from the doctor.

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Generic drugs should be cheap, but you still may be overpaying for them. I mentioned this problem in a previous post, but it bears repeating – your copay could be higher than an out-of-pocket price for some generic drugs. For example, 9 tablets of generic sumatriptan 100 mg can be purchased from a mail order pharmacy such as HealthWearhouse.com or a local pharmacy you can find on GoodRx.com for about $20. Your copay through your insurance plan could be $25 or much higher. Read more about this in a Bloomberg.com story.

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We’ve adopted electronic medical records (EMR) over 10 years ago when the upfront costs were high and the training curve was steep. One of the reasons for our early adoption was that we were running out of space for paper charts in our small Manhattan office. We also knew that EMR would improve the quality of care and safety – it allows us to see the lists of problems, allergies, medications, and other information at a glance on one screen. Sending prescriptions electronically dramatically reduces errors and saves time. Being able to log onto our system from home improved the after-hours care of our patients. We’ve never regretted implementing EMR years before EMR was mandated by the government.

Now for the negatives. A recent study by Dr. Christine Sinsky and colleagues published in the Annals of Internal Medicine is entitled, Allocation of physician time in ambulatory practice: A time and motion study in 4 specialties.

For this study, fifty-seven ambulatory care physicians in four specialties (family medicine, internal medicine, cardiology, orthopedics) in four states were directly observed for 430 hours. Twenty of these physicians also completed after-hours diaries. The results were striking: physicians spent 27% of their time on direct clinical face time and 49% on electronic health records and deskwork, while the rest was spent on administrative and other tasks. Even in the exam room, physicians spent 53% of the time on direct clinical face time and 37% on electronic health records and deskwork. They also spent 1-2 hours each night after office hours devoted primarily to electronic health records completion. The authors determined that for every hour physicians spent in direct clinical face time with patients, they spent additional 2 hours on electronic health records and deskwork during the clinic day and 1-2 hours of personal time finishing up electronic health records and deskwork at night.

So, when you see a doctor or a nurse practitioner, keep in mind that in addition to the time he or she spends with you, they have to spend twice as much time typing information into the computer, completing disability, insurance, and other forms, speaking to doctors and pharmacists, answering emails, staying up-to-date with latest medical discoveries, and doing other work. Dr. Neil Busis, writing in Neurology Today comments that the study confirms what we already know, that EHR use adds considerable clerical burden to practice. The study authors found that the use of EMR have decreased satisfaction and increased the risk for professional burnout. Physicians who burn out are at a significantly greater risk for depression and are more likely than satisfied colleagues to provide lower-quality patient care and to leave clinical practice early. Dr. Busis also notes that for many years the Centers for Medicare and Medicaid Services were telling doctors that they are not interested in listening to complaints until doctors can demonstrate that their policies will adversely affect their beneficiaries by decreasing access to care. This study provides such information. The idea is not to stop using EMR, but to reduce the need for meaningless tasks and to provide adequate compensation which accounts for all of the tasks doctor completes and not only for the face to face encounters.

I want to stress that, at least in our office, replacing paper charts with EMR has improved care of our patients, which in turn made our work even more satisfying. However, we would also love to spend less time doing paperwork.

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Estrogen-based oral contraceptives are usually contraindicated for women who have migraines with aura. In the latest issue of the journal Headache, Dr. Anne Calhoun of the Carolina Headache Institute argues that this contraindication is no longer valid.

She analyzes research studies that consistently show that stroke risk is not increased with today’s very low dose combined hormonal contraceptives containing 20-25 µg ethinyl estradiol and that continuous ultra low-dose formulations (10-15 µg) may even reduce the frequency of migraine auras. The past prohibitions were mostly based on the risk associated with contraceptives containing over 30 µg and often 50 µg of estradiol.

We often use continuous contraception (not having a period for 3 to 12 months) in women with menstrually-related migraines, which usually are not accompanied by aura.

There is no doubt that the risk of strokes in women with migraines with aura who take oral contraceptives is significantly increased by smoking and other stroke risk factors, such as hypertension, diabetes, high cholesterol, and other. So, women who have migraine with aura and take estrogen-based contraceptives should not smoke, should exercise regularly, have a healthy diet and have regular check-ups to detect conditions that may augment the risk of strokes. If such risk factors are present, progesterone-only or non-hormonal contraceptives should be used.

Dr. Calhoun also points out other benefits of oral contraceptives, besides the reduction of the chance of undesired pregnancy, relief of painful periods, excessive bleeding, acne, and PMS. These include reduction in death rate from any cause, 80% reduction in the risk of ovarian and endometrial cancers and reduced risk of colorectal cancer. On the other hand, oral contraceptives do increase the risk of breast cancer.

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Physical and mental symptoms can persist after a concussion and strangely, mild concussions are more likely to cause persistent symptoms than severe ones. In a previous post, Rest your brain after a head injury I described a study that involved 335 children and young adults. As the title indicates, cognitive rest was associated with a faster recovery.

Another post on concussion and post-concussion headaches mentioned that experts advocate physical rest as well. However, a new study of over 3,000 Canadian children between the ages of 5 and 18 with concussion suggests that the recovery is faster in those who get physically active within the first week of an acute concussion. Of the children who engaged in physical activity within the first week 29% had persistent post-concussive symptoms four weeks later compared to 40% of those who did not engage in any physical activity. This was true whether the child participated only in light aerobic exercise (33% of kids), sport-specific exercise (9%), noncontact drills (6%), full-contact practice (4%), or full competition (17%). I am very surprised that kids were allowed to return to full-contact practice and full competition before complete recovery.

These finding contradict all of the concussion guidelines, which recommend a period of physical and cognitive rest following a concussion until post-concussive symptoms such as dizziness, fatigue, and headaches have resolved. The guidelines also advise to increase the amount of physical activity only if symptoms do not worsen. These guidelines were developed without the benefit of large controlled studies, but rather by a consensus of experts.

The authors also think that children who rest for a long period of time may be unnecessarily deprived of physical activity’s benefits on the growing body. Too much rest may also lead to symptoms such as depression, anxiety, and social isolation.

“We may need to reconsider the current recommendations for strict conservative rest until patients are symptom-free,” study author Roger Zemek, MD, PhD, associate professor and director of research at the University of Ottawa in Canada, said in an interview with Neurology Today. “Patients should be encouraged to participate in some form of active physical rehabilitation following concussion as long as the activity does not put them at risk of re-injury.”

The study authors did caution that “Participation in activities that might introduce risk for collision or falls should remain prohibited until clearance by a health professional to reduce the risk for a potentially more serious second concussion during a period of increased vulnerability.”

Two prominent sports neurologists said that not much will change at their clinics, because programs like the one in the study are already in place. They generally prescribe an early, graduated, return to physical activity for children and adolescents who present with a sports-related concussion. (Phases include light activity like walking, moderate activity like jogging, and moderate-heavy activity like non-contact practice or drills.) Patients may return to full activity within one week, although they may not progress by more than one phase per day. These neurologists also felt that avoidance of all activity can be harmful – not just on physical health, but also on mental health.

They also agreed that kids must not be allowed to immediately return to full-contact sport or high risk activities before complete recovery because of the increased risk of re-injury.

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Italian researchers published a study in the journal Headache that attempted to correlate the attachment style in children with migraines with headache severity and psychological symptoms.

Attachment style typically develops in the first year of life. The premise of the study was derived from the attachment theory which suggests that early interpersonal relationships may determine future psychological problems and painful conditions. Previous studies have shown that people with insecure attachment styles tend to experience more pain than people with secure attachment style.

The study involved 90 children with migraines. The mean age was 12 years and there were 54 girls and 36 boys in the study. The kids were divided into a group with very frequent headaches (1 to 7 a week) and those with infrequent attacks – 3 or fewer per month. They also grouped them into those with severe pain, which interrupted their daily activities and those with mild pain that allowed them to function normally. The children were tested for anxiety, depression, and somatization (tendency to have physical complaints as a manifestation of psychological distress). They were also evaluated for the attachment style and were assigned into “secure,” “avoidant,” “ambivalent,” and “disorganized/confused” groups.

Interestingly, the researchers found a significant relationship between the attachment style and migraine features. Ambivalent attachment was present in 51% of children with high frequency of attacks and in 50% of those with severe pain. Anxiety, depression, and somatization were higher in patients with ambivalent attachment style. They also showed an association between high attack frequency and high anxiety levels in children with ambivalent attachment style.

The authors concluded: “We found that the ambivalent attachment style is associated with more severe migraine and higher psychological symptoms. These results can have therapeutic consequences. Given the high risk of developing severe headache and psychological distress, special attention should be paid to children with migraine showing an ambivalent pattern of attachment style. Indeed, a prophylactic and psychological therapy could often be necessary for these patients.”

People who have an anxious–ambivalent attachment style show a high desire for intimacy but often feel reluctant about becoming close to others and worry that people will not reciprocate their feelings. It is possible to mitigate the negative effects of the ambivalent attachment style even in adulthood. It does require a major effort and help from a psychotherapist.

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