Migraine and cluster headaches that do not respond to the usual treatments, may improve with injections of histamine.  Dr. Seymour Diamond of the Diamond Headache Clinic in Chicago has pioneered the use of histamine in cluster headaches.  We have found that in cluster headache patients for whom nothing else works histamine often provides excellent relief.  A recent study published in the journal European Neurology suggests that histamine injections may also help migraine patients.